Kwiga Kumisekuru Yumusatsi wa Autologous Platelet Rich Plasma (PRP)

Mu myaka ya za 90, impuguke mu by'ubuvuzi z’Ubusuwisi zasanze platine ishobora gutanga umubare munini w’imikurire yibitekerezo byinshi, bishobora gusana vuba kandi neza ibikomere byumubiri.Nyuma, PRP yakoreshejwe mububiko butandukanye bwimbere ninyuma, kubaga plastique, guhinduranya uruhu, nibindi.
Twabanje kumenyekanisha ikoreshwa rya PRP (Platelets Rich Plasma) muguhindura umusatsi kugirango dufashe gukira ibikomere no gukura umusatsi;Nibyo, ikigeragezo gikurikiraho kugerageza nukwongera ubwinshi bwimisatsi yibanze utera PRP.Reka turebe ibisubizo bizagerwaho mugutera inshinge zo mu bwoko bwa plaque ikungahaye kuri plasma hamwe nibintu bitandukanye bikura mubarwayi b'igitsina gabo barwaye alopecia, ari nawo muti dushobora kwitega gukoresha mu kurwanya umusatsi.
Mbere no mugihe cyose cyo guhinduranya umusatsi, abarwayi bavuwe na PRP nabatatewe na PRP barashobora gutuma umusatsi ukura vuba.Muri icyo gihe, umwanditsi yanasabye ubushakashatsi bwo kwemeza niba plasma ikungahaye kuri platel igira ingaruka zimwe mu kuzamura umusatsi mwiza.Ni ubuhe bwoko bw'igikomere kigomba gukoreshwa kandi ni bangahe bikura bigomba guterwa mu buryo butaziguye kugira ngo bigire akamaro?PRP irashobora guhindura imisatsi buhoro buhoro muri alopeciya ya andorogène, cyangwa irashobora gutuma imikurire ikura neza kugirango itere alopeciya ya andorogène cyangwa izindi ndwara zo guta umusatsi?
Muri uku kwezi kwa munani ubushakashatsi buto, PRP yatewe mumutwe wa alogeneya ya andorogène na alopecia.Ugereranije nitsinda rishinzwe kugenzura, rirashobora rwose guhindura imisatsi gahoro gahoro;Byongeye kandi, iyo batewe mu barwayi bafite uruhara runini, imikurire mishya irashobora kugaragara nyuma yukwezi kumwe, kandi ingaruka zishobora kumara amezi arenga umunani.

Intangiriro
Mu 2004, igihe umwe mu bashakashatsi yavuzaga igikomere cy'ifarashi na PRP, igikomere cyakize mu kwezi kumwe umusatsi urakura, hanyuma PRP ikoreshwa mu kubaga umusatsi;Abashakashatsi kandi bagerageje gutera PRP ku mutwe wa bamwe mu barwayi mbere yo guhindurwa umusatsi, basanga umusatsi w’abarwayi wasaga nkuwabyimbye (1).Abashakashatsi bemeza ko kuvugurura no guhindura ibintu byinshi bikura bishobora gutera imikurire y'utugingo ngengabuzima tw’imisatsi mu mutwe w’ahantu hadakorerwa.Amaraso atunganywa byumwihariko.Amashanyarazi yatandukanijwe nizindi poroteyine za plasma kandi zirimo umubyimba mwinshi wa platine.Kugirango ugere ku gipimo cy’ingaruka zo kuvura, kuva kuri microliter 1 (litiro 0.000001) irimo platine 150000-450000 kugeza kuri microliter 1 (litiro 0.000001) irimo platine 1000000 (2).
Platelet α ifite ubwoko burindwi bwibintu bikura muri granules, harimo gukura kwa epiteliyale, gukura kwa fibroblast, gukura kwa trombogene no guhindura ibintu bikura β 、 guhindura ibintu bikura α 、 Interleukin-1, hamwe niterambere ryimitsi y'amaraso (VEGF).Hiyongereyeho, peptide ya mikorobe, catecholamine, serotonine, Osteonectin, von Willebrand factor, proaccelenn nibindi bintu byongeweho.Ibice binini bifite ubwoko burenga 100 bwibintu bikura, bishobora gukora ku bikomere.Usibye ibintu bikura, plasma yihariye ya plasma (PPP) irimo molekile eshatu zifata ingirabuzimafatizo (CAM), Fibrin, fibronectin, na vitronectine, poroteyine ikora cyane igena imiterere nyamukuru n'amashami kugirango igenzure imikurire y'uturemangingo, gufatana, gukwirakwiza, gutandukana no kuvuka bundi bushya.

Takakura, n'abandi.yavuze ko ikimenyetso cya PDCF (platelet ikomoka ku mikurire yo gukura) gifitanye isano n’imikoranire y’imisatsi y’indwara ya epidermal na dermal tromal selile, kandi ni nkenerwa mu gushiraho imisatsi (3).Mu 2001, Yano n'abandi.yerekanye ko VFLGF igenga cyane cyane imikurire yimisatsi, itanga ibimenyetso bitaziguye byerekana ko kongera imisatsi yimitsi yimitsi ishobora kongera imisatsi no kongera umusatsi nubunini bwimisatsi (4).
PS: Platelet ikomoka kubintu bikura, PDCF.Ikintu cya mbere cyo gukura cyemejwe na FDA yo muri Amerika kuvura ibikomere byuruhu bidakira nicyo kintu cya mbere cyo gukura cyatewe no gukanguka nyuma yo gukomeretsa uruhu.
PS: Imitsi ikura ya endoteliyale, VEGF.Nibimwe mubintu byingenzi bigenga amategeko agenga ikwirakwizwa ry'uturemangingo twa endoteliyale, angiogenezi, vasculogenezi hamwe no gutembera kw'imitsi.

Niba twemera ko mugihe imisatsi yagabanutse kugeza aho tudashobora kubona imikurire yimisatsi n'amaso, haracyari amahirwe yo kumera umusatsi gukura umusatsi (5).Byongeye kandi, niba imisatsi yimisatsi myiza yimisatsi imeze nkiyimisatsi yoroheje, hariho selile stem zihagije muri epidermis na bulge (6), birashoboka ko umusatsi woroha kandi ukabyimbye mubusatsi bwumugabo.